Cell Line-derived Xenograft (CDX) Rat Model Services

Cell Line-derived Xenograft (CDX) Rat Models represent a premium preclinical evaluation system for oncology. By engrafting validated human cancer cell lines into immunodeficient rats, researchers can leverage a host that offers significant physiological advantages over murine models. Alfa Cytology provides end-to-end, fully customized rat CDX model development services. These platforms are specifically designed for drug developers requiring high-volume serial blood sampling, sophisticated surgical interventions, and integrated safety-efficacy assessments that only the rat physiology can accommodate.

The Strategic Advantage of CDX Rat Models

While mice are common for early screening, the Rat CDX Model is the preferred choice for advanced preclinical stages due to several critical factors:

Superior PK/PD Profiling: The larger blood volume of rats allows for serial microsampling from a single animal, providing high-resolution pharmacokinetic (PK) and pharmacodynamic (PD) data without the need for satellite groups.

Enhanced Toxicology Integration: Rats are the standard species for regulatory toxicology. Using Rat CDX models allows for the simultaneous evaluation of anti-tumor efficacy and dose-limiting toxicities (e.g., hematological or organ toxicity) in the same species.

Complex Surgical & Orthotopic Modeling: The anatomical size of the rat facilitates precise orthotopic implantation and complex surgical procedures, better simulating the tumor microenvironment (TME) in organs like the brain, liver, or pancreas.

Fig 1. Xenograft models in the SRG rat and NSG mouse. (Noto FK, et al., 2020)

Applications & Research Advancements in Rat CDX Modeling

Our Services

Validated Rat CDX Models Across Diverse Cancer Indications

Alfa Cytology maintains an extensive library of validated Rat CDX models characterized by their genomic profiles and standard-of-care (SoC) responsiveness. These platforms are optimized for long-term efficacy, safety assessments, and evaluating drug-resistant phenotypes.

Refer to the table below for our comprehensive list of available Rat CDX models:

Why Choose Alfa Cytology for Rat CDX Model Development?

Physiological Versatility

Expertise in rat-specific protocols optimized for high-volume serial sampling and complex surgical interventions.

Regulatory-Grade Compliance

Strict adherence to AAALAC guidelines and 3Rs principles, ensuring ethically-sound data for international IND filings.

Integrated PK/PD Analytics

Seamless transition from microsurgical model initiation to high-resolution pharmacodynamic and toxicological analysis.

Ready-to-Use Biobank

Immediate access to a vast repository of validated cell lines optimized for stable, long-term engraftment in rats.

Contact Us for Tailored CDX Rat Model Solutions

Alfa Cytology's integrated CDX rat model services provide a robust, physiologically superior platform to transform your preclinical oncology programs. From advanced PK/PD profiling to customized toxicological studies, we partner with you to generate reliable, translatable data. Contact us today to discuss how our specialized Rat CDX solutions can be tailored to accelerate your path to the clinic.

For research use only. Not intended for any clinical use.