Cell Line-derived Xenograft Mouse Model Services

Cell Line-derived Xenograft (CDX) Mouse Models represent a cornerstone of preclinical oncology, established by grafting validated human cancer cell lines into immunodeficient mice. These models faithfully recapitulate systemic drug metabolism and the fundamental interactions between tumors and host physiology. Alfa Cytology provides end-to-end, fully customized CDX model development services, enabling researchers and drug developers to leverage these highly translatable platforms for high-throughput drug screening, pharmacokinetic (PK/PD) assessment, and therapeutic validation.

Overview of CDX Mouse Models in Drug Discovery

CDX models serve as the essential bridge connecting early in vitro screening to advanced preclinical in vivo trials. By utilizing well-characterized human cancer cell lines, CDX models offer a highly standardized and reproducible environment to evaluate the anti-tumor activity of novel compounds.

In an era of precision medicine, CDX models remain the "Gold Standard" for obtaining preliminary data on Tumor Growth Inhibition (TGI). Their cost-effectiveness and rapid turnaround times make them the ideal platform for dose optimization and lead candidate selection before advancing to complex patient-derived or clinical phases.

Fig 1. CDX modes of A375 Vemurafenib R and A375 Dabrafenib R cell lines. (Hai-Ting Dai, et al., 2024)

Applications & Research Advancements in CDX Modeling

At Alfa Cytology, we maximize the utility of CDX platforms by integrating them with modern analytical techniques to address diverse R&D challenges:

Our Services

Comprehensive CDX Model Portfolio: Advanced Construction & Multi-Type Systems

At Alfa Cytology, we employ standardized and rigorous methodologies to ensure that every Cell Line-derived Xenograft (CDX) model delivers stable, reproducible, and clinically relevant data. By integrating diverse implantation techniques with stringent quality control, we provide a robust platform for evaluating a wide array of therapeutic modalities.

Our Precision Model Construction Methodology

To ensure high take rates and consistent growth kinetics, our CDX model development follows a specialized technical workflow:

Explore Our Full CDX Model Database

We maintain a vast and growing library of over 400 validated models covering major and rare cancer indications. Please refer to the table below for a comprehensive list of our available CDX models, categorized by cancer type and cell line:

Why Choose Alfa Cytology for CDX Model Development?

Tailored Model Development

Delivering customized protocols and tailored model development for unique research objectives, from small molecules to complex biologics.

High Standards of Animal Welfare

Operating in full compliance with AAALAC guidelines and 3Rs principles, ensuring ethically-sound data through rigorous protocol oversight.

Integrated Analytical Solutions

A seamless pipeline from model generation to downstream analysis, including cfDNA studies and comprehensive biomarker validation.

Extensive Model Biobank

Immediate access to a diverse collection of ready-to-use, validated CDX lines across numerous cancer indications to accelerate your timelines.

Contact Us for Tailored CDX Mouse Model Solutions

Alfa Cytology's integrated CDX mouse model development and research services provide a robust, translatable platform to transform your oncology research and preclinical development programs. From rapid activity screening to customized functional studies, we partner with you to generate reliable, human-relevant data. Contact us today to discuss how our CDX services can be tailored to advance your specific research objectives and accelerate your path to the clinic.

For research use only. Not intended for any clinical use.