Humanized Immune System Mouse Model Development Services
Humanized immune system mouse models have diverse applications across various cancer research fields. These models facilitate a deeper comprehension of the complex mechanisms underlying cancer development and progression. Moreover, they serve as a crucial experimental platform for devising novel therapeutic strategies, particularly in the rapidly evolving domain of immunotherapy. At Alfa Cytology, we are dedicated to offering cutting-edge humanized immune system mouse model development services, aiming to support researchers worldwide in advancing their cancer studies and accelerating the translation of scientific discoveries into effective clinical therapies.
Introduction to Humanized Immune System Mouse Model
Humanized immune system mouse models represent a groundbreaking advancement in preclinical research, designed to bridge the critical gap between in vitro studies and human clinical trials. These models are meticulously engineered by transplanting functional human immune cells, tissues, or hematopoietic stem cells (HSCs) into immunodeficient mice, creating a chimeric system that mirrors human immune responses in vivo. By replicating human-specific immune interactions, these models have become indispensable for evaluating novel immunotherapies, dissecting tumor-immune dynamics, and accelerating drug development with higher clinical relevance.
Fig. 1 Humanized mouse models. (Allen, T. M., et al., 2019)
Types of Humanized Immune System Mouse Model
Humanized immune system mouse models are powerful tools in biomedical research. These models are developed through various approaches to recapitulate key aspects of the human immune system in mice. Below are some common types of these models:
|
Description |
| Hematopoietic Stem Cell (HSC) Transplantation Model |
Human CD34+ HSCs, sourced from umbilical cord blood or bone marrow, are injected into neonatal mice. This process leads to the development of a multilineage human immune system, including T cells, B cells, dendritic cells, and monocytes. |
| Peripheral Blood Mononuclear Cell (PBMC) Engraftment Model |
By injecting adult PBMCs into mice, researchers can achieve rapid reconstitution of mature human T cells. This model is particularly suitable for short-term immunotherapy studies. |
| Human Cytokine Knock-in Model |
Strains like NSG-SGM3 feature transgenic expression of human cytokines such as GM-CSF, IL-3, and SCF. These models enhance myeloid cell survival and functionality, addressing previous limitations in modeling innate immunity. |
Our Services
Alfa Cytology offers advanced humanized immune system mouse models to bridge the gap between preclinical research and clinical outcomes. Our models replicate human immune responses, enabling robust evaluation of immunotherapies, tumor-immune interactions, and personalized treatment strategies for cancer research and drug development.
HuPBMC-T Engraftment Model
HuPBMC-T engraftment model development service focuses on the development of customized models for T-cell immunotherapy. This model focuses on T-cells and can accurately support your research and development in the field of T-cell immunotherapy, whether it is mechanism investigation or drug screening.
HuPBMC-NK Engraftment Model
For NK cell therapy, we provide HuPBMC-NK engraftment model development. It has the ability to reconstruct NK cells at the clinical level, and builds a high-quality simulation platform for your NK cell therapy-related projects, helping you to deeply analyze the function and therapeutic potential of NK cells.
HuPBMC-B Engraftment Model
HuPBMC-B engraftment model development service is ideal for B-cell therapy research. The model is capable of reconstructing B lymphocytes with antibody-secreting function, meeting your diverse needs for B cell therapy from basic research to drug development.
HuPBMC-MHC/KO Engraftment Model
HuPBMC-MHC/KO engraftment model is based on MHC knockout mice. Its significant advantage is that it can delay the onset of GVHD by more than 50%, providing a more stable and longer-lasting experimental model for your related immunological research and reducing experimental interference factors.
HuPBMC-Myeloid Engraftment Model
If your research focuses on immunotherapies that require antigen presentation, such as tumor vaccine development, our HuPBMC-myeloid engraftment model development service is a must-have. The simultaneous reconstruction of myeloid and lymphoid cells perfectly suits the complex needs of these immunotherapies, and is a powerful tool for the development of your innovative therapies.
More
Alfa Cytology has more special humanized immune system mouse model development services, no matter how unique your research direction is, we can provide you with the appropriate model solution to meet your wide range of needs in cancer therapeutic development, and we look forward to further serving you and opening up more research possibilities.
Are you seeking to overcome the limitations of traditional cancer models in capturing the intricate tumor complexity unique to each patient? Alfa Cytology's humanized immune system mouse model development services offer a cutting-edge solution. Our models are meticulously designed to retain tumor heterogeneity and clinical relevance, providing you with powerful tools to advance your research. Whether you're aiming to accelerate drug discovery, unravel resistance mechanisms, or tailor personalized therapies with precision, our platform integrates advanced technologies and expertise to support your goals. Contact us today to discover how our humanized immune system mouse models can transform your cancer research journey and drive innovation forward.
Reference
- Allen, T. M., et al. Humanized immune system mouse models: progress, challenges and opportunities. Nature immunology. 2019, 20(7): 770-774.
For research use only.
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