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Prostate Cancer Cell Line Customization Service
Stable cell lines play a crucial role in prostate cancer research and development of new therapies. Alfa Cytology offers a one-stop prostate cancer cell line development service, providing you with customized stable cell lines to ensure that your research projects can move forward with efficiency and precision.
Introduction to Prostate Cancer Cell Line
Prostate cancer cell lines are cell populations with certain biological characteristics extracted from prostate tissues and cultured and proliferated in vitro. These cell lines can be used to study the pathogenesis of prostate cancer, drug screening, gene function studies, and the development of new therapeutic strategies.
Types of Prostate Cancer Cell Line
In clinical practice, prostate cancer is closely associated with androgen receptor (AR) expression. Therefore, commonly used human prostate cancer cell lines are usually categorized into two main groups based on AR expression: androgen receptor-positive cell lines and androgen receptor-negative cell lines.
| Name | AR | Tumor Formation | Application |
| LNCaP | + | LNCaP cells can form tumors in nude mice. | Growth and metastasis studies, Androgen receptor function studies. |
| 22RV1 | + | 22RV1 cells are capable of forming PSA-positive tumors in nude mice. | Growth and metastasis studies, Androgen receptor function studies. |
| VCaP | + | VCaP cells are capable of forming tumors in both nude mice and SCID mice. | Growth and metastasis studies, Androgen receptor function studies. |
| PC3 | - | PC3 cells were grown in agar and produced tumors in nude mice. | Growth and metastasis studies |
| DU145 | - | DU145 cells can form adenocarcinoma (grade II) consistent with prostatic primary in nude mice. | Growth and metastasis studies |
Our Services
Alfa Cytology specializes in providing comprehensive cell line development services for prostate cancer research, including the construction and optimization of customized stable cell lines. Our dedicated team of professionals is committed to meeting your specific needs for cell models in drug discovery, compound screening and gene therapy research, ensuring that your research program is supported by high-quality, reliable cell lines.
Primary Cell Line
Different primary prostate cancer cell lines are provided by directly isolating and culturing cells from tumor tissue of prostate cancer patients.
iPS Cells
Provide various types of reprogrammed pluripotent stem cells that can be differentiated into prostate cancer cells through iPSC editing system.
CRISPR Knockout Cell Lines
Provides precise disruption of specific genes of interest in prostate cancer cell lines using proven CRISPR-Cas9 gene editing technology.
Knockdown Cell Lines
By using RNA interference (RNAi) technology, we achieved an effective reduction in the expression of specific target genes in prostate cancer cell lines.
Knockin Cell Lines
Knockdown Cell Line Service enables precise integration of exogenous DNA sequences into prostate cancer cell lines.
Overexpression Cell Lines
Overexpression Cell Line Service provides the generation of prostate cancer cell lines with controlled and stable overexpression of target genes.
Prostate Cancer Cell Lines from Alfa Cytology
| Name | Description |
| Mouse Derived Cell Lines | |
| RM-1 | Human prostate carcinoma cell line. |
| RM-1-Luc | The RM-1-Luc cell line is derived from RM-1 cell line with stable and high expression of Luciferase. |
| RM-1-B2m-KO | B2m gene knockout mouse cell line of RM-1. |
| RM1-hPSMA | PSMA gene humanized RM1 cell line. |
| Humanized Cell Lines | |
| LNCaP-Luc | Luciferase-labeled LNCaP cell line. |
| LNCaP-AR-Tg | LNCaP cell line expressing AR luciferase reporter gene. |
| LNCaP clone FGC | LNCaP clone FGC is a cell line exhibiting epithelial morphology that was isolated in 1977 by J.S. Horoszewicz, et al., from a needle aspiration biopsy of the left supraclavicular lymph node of a 50-year-old, White, male (blood type B+) with confirmed diagnosis of metastatic prostate carcinoma. |
| 22RV1 | 22RV1 is a human prostate carcinoma epithelial cell line derived from a xenograft that was serially propagated in mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft. |
| 22RV-1-Luc | Luciferase-labeled 22RV-1 cell line. |
| PC-3 | PC-3 is a cell line initiated from a bone metastasis of a grade IV prostatic adenocarcinoma from a 62-year-old, White, male. |
| PC3-Luc | Luciferase-labeled PC3 cell line |
| C4-2 | Human prostate carcinoma cell line. |
| DU 145 | Human prostate carcinoma cell line |
| VCaP | Human prostate cancer cell line |
With extensive experience and advanced platforms, we offer you the best solution for customized cell lines for prostate cancer. Our company is a world leader in prostate cancer therapy development. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
For research use only.