Breast Tumor-on-Chip Modeling Services
Breast tumor-on-chip modeling uses microfluidic devices to simulate the breast tumor microenvironment, replicating physiological conditions. This approach enables researchers to study cancer biology, drug responses, and tumor-stroma interactions more accurately than traditional 2D cultures. Alfa Cytology offers a comprehensive suite of breast tumor-on-chip modeling services tailored for research and clinical applications.
Introduction of Breast Tumor-on-Chip Models
The breast tumor-on-chip model operates based on principles of physiological simulation, creating an environment closely mirroring natural conditions in breast tissue. Utilizing microfluidic chip systems to mimic the intricate microenvironment of the breast, this model provides a more realistic and biologically relevant platform for investigating breast cancer (BC). The 3D microfluidic model facilitates detailed cellular interactions, offering insights into tumor growth and dissemination mechanisms. The innovative design of breast tumor-on-chip models seeks to deepen our understanding of BC, expedite drug development, and drive personalized medicine research forward. This approach holds the promise of advancing our knowledge and refining our strategies in the fight against BC.
Fig.1 An example of the use of a breast tumor-on-chip. (Subia B, et al., 2021)
Our Services
Alfa Cytology breast tumor-on-chip model features microfluidic chips that facilitate the three-dimensional cultivation of cancerous and non-cancerous breast cells, closely mimicking the actual growth and interaction patterns within the human body. We offer a range of services for your needs:
- Microfluidic chip design and manufacturing
We specialize in designing and manufacturing microfluidic chips tailored to simulate the growth environment of breast tissue and tumors. - Cell culture and seeding
We assist you in cultivating both malignant and non-malignant breast on a chip, mimicking the cell interactions and growth in real biological organisms. - Drug testing and evaluation
We support your drug testing efforts on the chip, evaluating the impact of drugs on breast tumors and providing insights into efficacy and potential side effects. - Disease modeling
Our focus is on helping you utilize chip models to study the pathogenesis of BC, exploring a deeper understanding of tumor behavior in microenvironments.
Application Fields
Advantages of Our Services
- Interdisciplinary team collaboration
- Customized microfluidic chip designs
- Comprehensive support
Case Study
Human Mammary Gland-on-a-Chip Microphysiological System
- Model Introduction
This model serves as a physiologically relevant and human-mimetic platform for studying mammary gland development, drug efficacy testing, toxin exposure, and disease modeling—particularly valuable for investigating hormone responses, cancer progression, and personalized treatment strategies in a human-cell-based microenvironment.
- Model Information
- Model: Human Mammary Gland-on-a-Chip
- Fabrication: Micro-nanofabrication Technology
- Architecture: Microfluidic Channels with Biomimetic Structures
- Cancer Type: Invasive Breast Cancer
- Cell Components: Mammary Epithelial and Stromal Cells
- Model Construction
The model is constructed using micro-nanofabrication techniques to create microfluidic channels and biomimetic structures on a chip. Mammary epithelial cells and stromal cells are co-cultured in a three-dimensional configuration under static or dynamic conditions to form tissue-like structures. Culture medium, along with bioactive molecules such as hormones or drugs, is perfused through the microchannels under controlled flow rates and direction to simulate the in vivo mammary microenvironment.
- Model Data
- Structural Biomimicry: Maintains native mammary gland architecture with ductal-alveolar structures.
- Controlled Microenvironment: Enables sustained culture stability through continuous perfusion.
- Real-time Monitoring: Supports dynamic analysis of cellular responses under physiological conditions.
Fig. 2 Schematic diagram of breast cancer organ-on-a-chip. (Source: Alfa Cytology)
Alfa Cytology boasts extensive expertise in BC research garnered over many years. We are committed to continuous innovation, perpetually exploring improved solutions for our clientele, ensuring the delivery of top-notch products and services. If you are interested in learning more about our breast tumor-on-chip modeling services, please don't hesitate to contact us. Our dedicated and knowledgeable staff will promptly get in touch with you.
Reference
- Subia B, et al. Breast tumor-on-chip models: From disease modeling to personalized drug screening. J Control Release. 2021 Mar 10; 331: 103-120.