Thyroid Cancer Xenograft Models
Contact UsThyroid Cancer Xenograft Models are established by implanting human thyroid cancer cell lines, such as TPC-1 and K1, into immunocompromised mice. These models create a controlled and simulated environment that closely mirrors the biological behavior of thyroid tumors, offering valuable insights into tumor characteristics. By utilizing these xenograft models, researchers can effectively investigate various aspects of thyroid cancer, including tumor growth dynamics, metastatic spread, drug sensitivity, and therapeutic effectiveness. Moreover, these models serve as robust experimental platforms for evaluating novel therapeutic approaches and understanding the underlying molecular mechanisms driving thyroid cancer progression, ultimately contributing to the development of more effective treatment strategies.
These models retain the genetic diversity and histological features of original tumors, allowing for personalized treatment predictions based on patient responses to various therapies.
Various implantation methods—such as subcutaneous and orthotopic—enable the study of tumor behavior in more clinically relevant settings. In vivo imaging techniques help monitor tumor growth and metastasis in real-time.
They provide valuable information about driving signaling pathways and resistance mechanisms, aiding in the understanding of tumor biology and treatment outcomes.
Creation of thyroid cancer xenograft models typically involves injecting thyroid cancer cell lines into the target area of immunocompromised mice (e.g., NOD/SCID or NSG mice) through subcutaneous, orthotopic, and intravenous injection methods. These techniques allow researchers to effectively study tumor behavior, growth patterns, and treatment responses in a controlled environment.
Model Construction and Optimization
We offer Patient-Derived Xenografts (PDX) using fresh or frozen tumor tissues to preserve heterogeneity and molecular features, as well as Cell Line-Derived Xenografts (CDX) using standardized thyroid cancer cell lines. Tailored implantation methods include subcutaneous, orthotopic, and metastatic models.
Immunodeficient Mouse Adaptation
We utilize high-tumor-take NSG mice for aggressive subtypes and humanized mice for immune therapy studies. Dual-humanized models are also available to improve drug metabolism predictions.
Genetically Engineered Enhanced Models
Our gene editing services can knock out resistance genes or introduce reporter genes and activate signaling pathways to study tumor behavior.
Dynamic Monitoring and Phenotypic Analysis
We apply in vivo imaging techniques (bioluminescence, MRI/PET-CT) for real-time monitoring of tumor growth and angiogenesis, validated by molecular pathology through histological and genomic analyses.
Drug Testing and Efficacy Evaluation
Our platforms enable preclinical studies of single or combination therapies and simulate radioactive iodine (RAI) treatment for efficacy assessments.
Data Integration and Bioinformatics Support
We conduct multi-omics analyses (e.g., single-cell RNA sequencing), validate clinical relevance by comparing model data against databases like TCGA, and confirm molecular characteristics.
Alfa Cytology is your trusted partner for developing thyroid cancer xenograft models, supported by our extensive expertise in oncology research. We provide ready-to-use models, customizable options, and collaborative R&D services tailored to your specific requirements. From comprehensive solutions to detailed reports, we offer full support throughout the process. Please get in touch with us with any inquiries or to discuss custom model development.
For research use only.
