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Xenograft Mouse Models for Pancreatic Cancer

Xenograft Mouse Models for Pancreatic Cancer

Alfa Cytology is a leading preclinical research service provider. We have extensive experience constructing transplantation models for pancreatic cancer (PC). Based on our comprehensive expertise in this area and advanced technology platform, we can develop various PC xenograft models for our customers for research and preclinical purposes.

Overview of Transplantation Models

Transplantation models involve the transplantation of mouse or human cells/spheres/organoids/tissues into recipient mice. Compared to genetically engineered mouse models (GEMMs), transplantation models are easier to handle and have a relatively low and more predictable tumor latency. Transplantation models can be classified as in situ implantation models (in the pancreas) or ectopic implantation models (subcutaneous, intraperitoneal, intravenous, intrapleural, or intracardiac) depending on the location of cell implantation.

Transplanted tumors are most commonly used to test the therapeutic effects of various anti-cancer drugs. Fig. 1 Generation of allograft and xenograft transplantation models. (Jana, R., et al., 2023)

Moreover, according to the transplant source, transplantation models can be divided into syngeneic (allograft) and xenogeneic (xenograft). The allograft models are established by transplanting mouse-derived tumor cells and tumors into mice. In contrast to the allograft model, xenografts require the implantation of human tumors or cancer cells into immunocompromised mice, and PC cell lines or spheroids serve as common sources for transplantation.

Our Services

Over the past decades, xenograft models have been the backbone of cancer research, providing an effective environment for studying and evaluating novel therapies. We can construct different types of xenograft models for PC research. Several xenograft models of PC are available for our customers to choose from.

Xenograft Models of Pancreatic Cancer
Models Descriptions Applications

Cell line-derived xenografts (CDXs)
  • Transplanting PC cell lines into immunocompromised mice.
  • MIA PaCa-2, BxPC-3, PANC-1
  • Testing the efficacy of anti-cancer therapies in vivo.

Spheroid-based xenografts (SDXs)
  • Transplanting 3D spheroid into immunocompromised mice.
  • Showing increased expression of pro-fibrotic and pro-survival PC markers compared to cell-based counterparts.
  • Testing the efficacy of anti-cancer therapies in vivo.

Organoid-derived xenografts (ODXs)
  • Orthotopic transplantation of human pancreatic tumor organoids into immunocompromised mice.
  • Recapitulating the full spectrum PC progression.
  • Investigating PC progression in vivo.
  • Investigating early biomarkers for therapeutic and diagnostic development.

Patient-derived xenografts (PDXs)
  • Transplanting a piece of human tumor tissue derived from surgical resection or tumor biopsies into immunocompromised mice.
  • Preserving morphological features of the primary tumor and its metastatic potential.
  • Recapitulating PDAC tumor heterogeneity, genetics, and microenvironment.
  • Identifying new biomarkers and performing drug testing.
  • Serving as tools for personalized treatments of PDAC patients.

Besides, we also offer a complete suite of laboratory services, including but not limited to the following.

  • Transplantation study design
  • Selection of appropriate cell line/cancer model
  • Host animal selection
  • Subcutaneous or orthotopic xenografts

Why Choose Us?

Scientific Experience

Professional team of scientists and more than ten years of experience in pancreatic cancer

Customized Service

Tailored services dedicated to ensuring customer satisfaction

Data Security

Strictly keep confidential the client's project information and experimental data

Quick Reply

Our customer service representatives are available 24 hours a day from Monday to Sunday

Xenograft models serve as powerful research tools. CDXs are widely used in preclinical studies because of their low cost, rapid and efficient drug screening, and simple tumor size assessment. The xenograft models are significantly improved by establishing PDXs, thus bypassing the need for cancer cells to adapt to cell culture conditions. If you are interested in our services, please contact us for more details. You can contact our staff directly and receive professional, reliable, and fast feedback.

Reference

  1. Jana, R., et al.; Mice as an Experimental Model to Understand the Pathobiology of Diseases. 2023. DOI:10.5772/intechopen.1001835.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.