| Size | 10 mg/50 mg |
| Synonyms | XAV939 Wnt Signaling Inhibitor |
| Purity | ≥98% |
| Formula | C14H11F3N2OS |
| Molecule Mass | 312.31 |
| Chemical Name | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| SMILES | OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1 |
| Target | Tankyrase |
| Biological Activity | XAV 939 is a potent inhibitor of tankyrase 1 (TNKS1, IC50 = 11 nM) and tankyrase 2 (TNKS2, IC50 = 4 nM). By inhibiting tankyrase, it stabilizes axin and stimulates β-catenin degradation, thereby antagonizing Wnt signaling. |
| Appearance | Solid |
| Color | White to off-white |
| Solubilization | The compound is soluble to 20 mM in DMSO |
| Storage | Store at room temperature. |
| Shipping Information | Room temperature |
For preclinical research and development use only; not intended for therapeutic or other applications.
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