| Size | 1 mg/10 mg/50 mg |
| Purity | ≥98% |
| Formula | C25H22N6.2HCl |
| Molecule Mass | 479.4 |
| Chemical Name | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| SMILES | N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl |
| Target | ALK2, ALK3, and BMP4 |
| Biological Activity | LDN 193189 dihydrochloride is a potent and selective inhibitor of ALK2 and ALK3, with IC50 values of 5 nM and 30 nM, respectively, and effectively blocks BMP4-mediated Smad1/5/8 activation. |
| Appearance | Solid |
| Color | Orange to red |
| Solubilization | The compound is soluble to 50 mM in water and to 10 mM in DMSO |
| Storage | Store at -20°C |
| Shipping Information | Room temperature |
For preclinical research and development use only; not intended for therapeutic or other applications.
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