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IWP 4

Cat. No.: SMOC-2603-CXX-022

Description: A powerful antagonist of the canonical Wnt/β-catenin signaling pathway.

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Datasheet: Datasheet

Product Details

Size 10 mg/50 mg
Purity ≥98%
Formula C23H20N4O3S3
Molecule Mass 496.62
Chemical Name N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
SMILES O=C1C3=C(CCS3)N=C(SCC(NC4=NC(C=CC(C)=C5)=C5S4)=O)N1C2=C(OC)C=CC=C2
Target Wnt/β-catenin
Biological Activity IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM) with minimal effects on the Notch and Hedgehog pathways. It is primarily used to induce cardiomyocyte differentiation from human ESCs and iPSCs.
Appearance Solid
Color White to light yellow
Solubilization The compound is soluble to 1 mM in DMSO

Storage & Handling

Storage Store at +4°C
Shipping Information Room temperature

For preclinical research and development use only; not intended for therapeutic or other applications.