Cat. No.: ROOC-2603-CXX-002
Description: Drug-induced liver injury (DILI), damage caused by drugs or their metabolites, is among the most frequent serious adverse drug reactions and a leading cause of trial failures. Three-dimensional models using human primary hepatocytes (PHHs) provide an ideal in vitro platform for evaluating hepatotoxicity, metabolic enzyme induction and inhibition, and drug metabolism.
Price: Inquiry
Datasheet: Datasheet
| Advantages | Relative to 2D PHH cultures, the 3D PHH microfluidic model demonstrates enhanced viability, with cell health continuing to improve throughout this period. This 3D system also exhibits more physiologically relevant liver function, supporting higher and stable albumin and urea production. Furthermore, CYP450 enzyme expression is significantly upregulated in the 3D model compared to 2D, and enzyme activity remains stable during extended culture. |
| Species | Human |
| Product Type | Organoid-on-a-Chip |
| Disease | Normal |
| Applications | Facilitates hepatotoxicity screening, drug metabolism profiling, and assessment of metabolic enzyme induction and inhibition. |
For preclinical research and development use only; not intended for therapeutic or other applications.
Alfa Cytology is a preclinical research service provider specializing in tumor organoid development. We provide one-stop services that include tailored 3D cancer models, organoid-based research services, and related products to accelerate the discovery and development of cancer therapeutics.
Copyright © 2026 Alfa Cytology. All rights reserved.
