| Size | 1 mg |
| Synonyms | γ-Secretase Inhibitor XXI |
| Purity | ≥98% |
| Formula | C27H24F2N4O3 |
| Molecule Mass | 490.5 |
| Chemical Name | N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| SMILES | C[C@@H](C(N[C@H]1N=C(C2=CC=CC=C2N(C1=O)C)C3=CC=CC=C3)=O)NC(CC4=CC(F)=CC(F)=C4)=O |
| Target | γ-secretase |
| Biological Activity | Compound E is an inhibitor of γ-secretase and the Notch signaling pathway. In combination with DAPT and 13-cis retinoic acid, it enhances the growth inhibition, differentiation, and migration of neuroblastoma cells. |
| Appearance | Solid |
| Color | White to light yellow |
| Solubilization | The compound is soluble to 100 mM in DMSO |
| Storage | Store at -20°C |
| Shipping Information | Room temperature |
For preclinical research and development use only; not intended for therapeutic or other applications.
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