Cervical Cancer Genetically Engineered Mouse Models

Introduction to Genetically Engineered Mouse Models

Genetically Engineered Mouse Models (GEMMs) are specially modified mice that replicate key aspects of human diseases, particularly cervical cancer. Utilizing advanced gene editing techniques, GEMMs can accurately simulate genetic mutations and tumor microenvironments found in cervical cancer. This precise modeling allows researchers to investigate the disease's mechanisms, assess therapeutic strategies, and evaluate drug efficacy, making GEMMs essential tools in advancing cervical cancer research.

Fig. 1 Applications of GEMMs in basic cancer research and translational oncology.(Kersten K, et al., 2017)

Our Services

At Alfa Cytology, we offer a range of Genetically Engineered Mouse Models (GEMMs) tailored for cervical cancer research, designed to mimic the disease progression through various genetic modifications. Our available GEMMs services include:

HPV Transgenic Mouse Models

These models incorporate the oncogenes of HPV, such as E6/E7, into the mouse genome using gene editing or transposon techniques. They are specifically expressed in cervical epithelial tissues, allowing researchers to investigate HPV-mediated carcinogenic mechanisms and test antiviral therapies.

Conditional Knockout/Knock-in Models

Utilizing the Cre-loxP system, we offer models that allow for time- and tissue-specific deletion of tumor suppressor genes like p53 or PTEN, or the activation of oncogenic mutations. These models enable precise control of genetic alterations to study specific signaling pathways, such as the PI3K/AKT pathway, in cervical cancer development.

Humanized Immune Checkpoint Models

By introducing human immune checkpoint molecules (e.g., PD-1, CTLA-4) into immunocompetent mice, these models retain a fully functional immune system, facilitating the evaluation of immunotherapy efficacy, including the testing of PD-1 inhibitors and combination treatment strategies.

Compound Mutation Models

Combining HPV transgenes with host gene mutations (e.g., E6/E7 with p53 knockout), these models accelerate tumor progression and enhance clinical relevance, providing a platform to investigate multifactorial carcinogenic mechanisms and targeted combination therapies.

Applications of Cervical Cancer GEMMs

Mechanism of Disease Research

GEMMs replicate the genetic mutations and abnormal signaling pathways of human cervical cancer, helping to uncover the disease's underlying mechanisms. Studying the oncogenic effects of HPV16 E6/E7 in these models enhances our understanding of HPV's role in cervical cancer.

Drug Screening and Therapeutic Strategies

GEMMs serve as a robust platform for screening drugs and validating treatment strategies. By expressing specific genes, these models allow researchers to test the effectiveness of potential therapies in inhibiting tumor growth.

Immunotherapy Research

GEMMs facilitate the exploration of immunotherapy mechanisms in cervical cancer. Genetically modified mice enable evaluation of T cell targeting against HPV16 E7, supporting the development of novel immunotherapeutic approaches.

Alfa Cytology is your ideal partner for developing GEMMs for cervical cancer research, supported by our extensive expertise in oncology. We provide ready-to-use GEMMs, customizable options, and collaborative R&D services to meet your specific requirements. With comprehensive support from model development to detailed reports, we ensure you have all the resources you need. Contact us for inquiries or to discuss custom GEMMs development.

For research use only.