Cat. No.: ROTC-2603-CXX-001
Description: Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment, promoting tumor cell proliferation, drug resistance, invasion, and metastasis through the secretion of factors such as TGF-β, HGF, and IL-6. CAFs also contribute to tumor progression by supporting angiogenesis and lymphangiogenesis, remodeling the extracellular matrix, suppressing anti-tumor immunity, and inducing epithelial-mesenchymal transition in cancer cells. Consequently, targeting CAFs has emerged as a promising strategy in anticancer drug development.
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