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TM2 TEAD Inhibitor

Name: TM2 TEAD Inhibitor
Brand: Alfa Cytology
SKU: SMOC-2603-CXX-043

Cat. No.: SMOC-2603-CXX-043

Description: A potent, reversible inhibitor of TEAD transcription factor activity within the Hippo/YAP pathway.

Price: Inquiry

Datasheet: Datasheet

Product Details

Size	10 mg/50 mg
Purity	≥98%
Formula	C26H33N3O3
Molecule Mass	435.57
Chemical Name	4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
SMILES	O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4
Target	TEAD mediated Hippo/Yap signalling
Biological Activity	TM2 TEAD inhibitor is a potent and reversible inhibitor of TEA domain transcription factors, with IC50 values of 38 nM for TEAD4 auto-palmitoylation and 156 nM for TEAD2 palmitoylation. It disrupts the TEAD-YAP association and inhibits downstream transcriptional activity.
Appearance	Solid
Solubilization	The compound is soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage & Handling

Storage	Store at -20°C
Shipping Information	Room temperature

For preclinical research and development use only; not intended for therapeutic or other applications.