| Size | 1 mg/10 mg/50 mg |
| Purity | ≥99% |
| Formula | C22H16N4O3 |
| Molecule Mass | 384.39 |
| Chemical Name | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| SMILES | NC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=N1)C1=CC2=C(OCO2)C=C1 |
| Target | TGF-βRI, ALK4 and ALK7 |
| Biological Activity | SB 431542 is a potent and selective inhibitor of the TGF-β type I receptor ALK5 (IC50 = 94 nM) and its relatives, ALK4 and ALK7. It suppresses TGF-β-induced proliferation in human osteosarcoma cells and can replace SOX2 in the reprogramming of fibroblasts into iPSCs. |
| Appearance | Solid |
| Color | Off-white to yellow |
| Solubilization | The compound is soluble to 10 mM in ethanol and to 100 mM in DMSO with gentle warming |
| Storage | Store at room temperature. |
| Shipping Information | Room temperature |
For preclinical research and development use only; not intended for therapeutic or other applications.
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