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Model of the Tumor Immune Microenvironment

Cat. No.: ROTC-2603-CXX-002

Description: Tumor immunotherapy has been a major focus of cancer research in recent years. While numerous agents targeting the tumor immune microenvironment, particularly immune checkpoint blockers, are in development, the field still lacks highly predictive models for preclinical evaluation. Current in vitro approaches often rely on tumor cell lines and commercial immune cells, which have limited relevance. To address this gap, a tumor immune microenvironment model has been developed that uses patient-matched tumor organoids and PBMCs.

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Product Details

Advantages This system faithfully replicates critical aspects of the in vivo tumor immune microenvironment, offering a physiologically relevant platform for immuno-oncology drug discovery and development.
Species Human
Product Type Organoid-on-a-Chip
Disease Cancer
Organoid Characterization The frequency of CD8+ CD137+ T cell subsets is significantly increased in PBMCs following co-culture with tumor organoids.

Application

Applications Enables evaluation of immune checkpoint inhibitors and cell-based therapies, as well as predictive assessment of cytokine release syndrome.

For preclinical research and development use only; not intended for therapeutic or other applications.