| Advantages | They are well-suited for studying initial differentiation events and early brain development, providing insights into the formation and maturation of midbrain cell types. |
| Species | Human |
| Product Type | iPSC-derived Organoid |
| Growth Properties | Embedded 3D Culture |
| Growth Conditions | Cultured at 37°C under 95% air and 5% CO2. |
| Quality Control | Negative for mycoplasma, bacteria, yeast, and fungi. |
| Tissue | Midbrain |
| Disease | Normal |
| Format | Frozen |
| Organoid Characterization | Scanning electron microscopy shows spherical, healthy cell populations, predominantly neuronal, with maturation timelines closely following human cortical development. At 2 months, these organoids are in early neurogenesis, composed mainly of neural progenitors and immature neurons. |
| Applications | Human iPSC-derived midbrain organoids are 3D models generated from human induced pluripotent stem cells via directed differentiation. They recapitulate key structural and functional features of native tissues, displaying self-organization and complex biological behaviors. These 3D in vitro models reflect the cellular composition of the brain and show robust expression of the dopaminergic neuron marker TH and the progenitor markers FOXA2 and OTX2. They also exhibit functional properties, including spontaneous neuronal activity. |
| Storage | Liquid Nitrogen |
| Shipping Information | Dry Ice |
For preclinical research and development use only; not intended for therapeutic or other applications.
Alfa Cytology is a preclinical research service provider specializing in tumor organoid development. We provide one-stop services that include tailored 3D cancer models, organoid-based research services, and related products to accelerate the discovery and development of cancer therapeutics.
Copyright © 2026 Alfa Cytology. All rights reserved.