Cat. No.: ROOC-2603-CXX-001
Description: The human intestine performs multiple essential functions, including serving as a physical barrier, facilitating digestion and nutrient absorption, and supporting motility. In addition, it plays a key role in systemic physiology through drug metabolism and bidirectional communication with the gut microbiota and other organ systems.
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Datasheet: Datasheet
| Advantages | Unlike conventional Caco-2 Transwell systems, this intestinal model uses human intestinal organoids and incorporates physiologically relevant fluid shear forces found in the tissue microenvironment. This approach more accurately recapitulates normal human physiology at the cellular level, providing a superior platform for pharmaceutical ADME studies. |
| Species | Human |
| Product Type | Organoid-on-a-Chip |
| Disease | Normal |
| Organoid Characterization | Intestinal differentiation markers, including villin, Mucin 2, and components of the glycocalyx, are expressed and localized to the apical surface of colonic epithelial cells. |
| Applications | Applications include assessing drug absorption, metabolism, and transport; modeling intestinal inflammation; and investigating gut flora interactions. |
For preclinical research and development use only; not intended for therapeutic or other applications.
Alfa Cytology is a preclinical research service provider specializing in tumor organoid development. We provide one-stop services that include tailored 3D cancer models, organoid-based research services, and related products to accelerate the discovery and development of cancer therapeutics.
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