| Size | 10 mg/50 mg |
| Synonyms | IWR-1-endo |
| Purity | ≥98% |
| Formula | C25H19N3O3 |
| Molecule Mass | 409.44 |
| Chemical Name | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
| SMILES | [H][C@]13[C@](C(N(C4=CC=C(C(NC5=CC=CC6=C5N=CC=C6)=O)C=C4)C3=O)=O)([H])[C@H]2C=C[C@@H]1C2 |
| Target | Wnt/β-catenin |
| Biological Activity | endo-IWR 1 is a Wnt signaling inhibitor that stabilizes Axin-scaffolded destruction complexes. This stabilization leads to increased Axin2 protein levels and promotes β-catenin phosphorylation. |
| Appearance | Solid |
| Color | Off-white to yellow |
| Solubilization | The compound is soluble to 100 mM in DMSO |
| Storage | Store at room temperature. |
| Shipping Information | Room temperature |
For preclinical research and development use only; not intended for therapeutic or other applications.
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